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Diurnal State Modulation
Morning · Activate (06–12) Midday · Cognitive prime (12–15) Social · Perform (15–20) Wind down (20–22) Sleep onset (22–00) Deep recovery (00–06)
06:00 · Activation

The body you wake up in is not the body you fall asleep in.

The world's first Diurnal State Modulation system. Activate, perform, recover.

Drag the arc · scroll the science
Start here

Supplements are confusing.

Hundreds of pills, powders and promises — most of it noise. So let's strip it back to first principles and explain, plainly, What You Need.

First principles · the body

Before any pill — what does a body need?

Strip it back and every human runs on six essentials. Get these right from real food and water, and most of the supplement aisle is noise.

Your body makes this

No need to supplement

Given decent raw materials, you manufacture these yourself.

  • Most amino acidsbuilt from the protein you eat
  • Glucosemade from carbs, protein or fat as needed
  • Cholesterolthe liver makes most of it
  • Vitamin Dmade in skin from sunlight
  • Creatinepart-made in the liver and kidneys
Your body can't make these — but food can

These are "essential"

No machinery to build them. Miss the food, miss the nutrient.

  • 9 amino acidsfrom eggs, fish, meat, soy
  • Omega-3 / 6 fatsfrom oily fish, walnuts, seeds
  • Vitamins A–Kfrom colourful veg, liver, dairy
  • Iron, zinc, magnesiumfrom red meat, legumes, greens
  • Calcium, iodinefrom dairy, leafy greens, fish
So who actually needs a supplement?

If you eat a varied diet — almost no one.

The genuine exceptions are specific people with a specific gap — not everyone:

Little sun / winter → Vitamin DVegan → B12No oily fish → Omega-3

That's the whole list. It is never a reason for a 40-ingredient multivitamin.

So WYN doesn't plug nutrition holes — eat well and nutrition is handled. WYN does the one thing a balanced plate can't: put the right active in your body at the right hour.

Eat across these groups and a multivitamin is largely redundant.
A multivitamin is a low-dose safety net for a diet you'd be better off fixing. WYN is not a multivitamin. It doesn't try to refill nutrients real food already gives you.
First principles · the timing

You know what your body needs.
Now — when does it need it?

Food answers the what. But the same meal lands differently at 8am and 10pm, because your metabolism runs on a clock too. There's no single right pattern — there's a right rhythm. Here are your choices, and what the science actually says.

So — when do you eat?

Tap the hours you usually eat. We'll name your pattern, read back your eating window and overnight fast, and show where WYN lands against your day. Change it anytime.

First — tell us about your day-to-day. We'll personalise the read-out.

Tap each hour you eat

Tap any hour to add a meal
WYN Morning WYN Social WYN Night
midnightnoonmidnight

Tap to add · tap again to remove · try OMAD, 16:8, three meals

Your pattern
—
Eating window
—
Overnight fast
—
How your body handles this pattern · desk job

The honest physiological trade-off

What your body loves
    What your body struggles with

      How WYN fits your day

      What the latest science actually says

      Drawn from 2025–26 randomised trials and meta-analyses on time-restricted eating. The headline: rhythm beats rules.

      Earlier wins

      The 2026 network meta-analysis is consistent: morning-weighted eating beats late eating for glucose, blood pressure and waistline.

      ~12-hour overnight gap

      Last food around 7pm, first around 7–9am. A clean overnight fast captures most of the upside without the extremes.

      Stop ~3 hrs before bed

      Late meals blunt deep sleep, spike overnight glucose and stall the repair window your body opens after dark.

      It's rhythm, not magic

      Matched-calorie trials show timing shifts your body clock — but how much and how well you eat still decides most of the result.

      And autophagy? Fasting does ramp up the body's cellular clean-up — but most of that data is animal or short-term. Treat the longevity headlines as promising, not proven. A consistent daily rhythm is the part the evidence actually backs.

      There's no perfect number of meals. There's a perfect rhythm — eat in daylight, front-load the day, and stop early.

      General education, not medical or dietary advice. Fasting and time-restricted eating aren't right for everyone — if you're pregnant or breastfeeding, under 18, underweight, diabetic or on blood-sugar/blood-pressure medication, or have any history of disordered eating, speak to a qualified professional before changing how you eat. Whatever pattern you choose, WYN times its actives to your day — Morning, Social and Night map to the clock, not to your meals.

      The real question

      If food covers everything — why supplement at all?

      Because "enough to avoid deficiency" and "enough to change how you function" are two completely different doses. Food does the first. It can't do the second.

      Deficient
      Symptoms, fatigue, illness. The thing supplements were invented to fix.
      Sufficient — food's ceiling
      A good diet gets you here. Healthy, not deficient. This is as far as eating well can take you.
      Elevated — WYN's job
      Where you actually excel — a measurable shift in state: energy, focus, calm, sleep depth. Only reachable at a dose food can't deliver.

      A flawless diet takes you to sufficient. It physically cannot take you to elevated.

      To reach elevated, you'd have to eat the impossible.

      These are the doses that actually shift how you feel. Here's what you'd have to eat to hit them — every day, on time. You can't.

      3,000mg
      Creatine
      You'd have to eat
      ~700 g of raw beef — every single day.
      Not happening
      3,000mg
      Glycine
      You'd have to drink
      ~1.5 L of bone broth — right before bed, nightly.
      Not happening
      2,000mg
      L-Tyrosine
      You'd have to eat
      A pile of high-protein food — and the free-form dose still wouldn't land on cue.
      Not happening
      300mg
      KSM-66 Ashwagandha
      You'd have to find
      A standardised root extract — it isn't a food at all.
      Impossible to eat
      100mg
      CoQ10
      You'd have to eat
      ~1 kg of sardines — and it still drops with age.
      Not happening
      100mg
      Theacrine
      You'd have to source
      One rare kucha tea fruit — effectively un-eatable.
      Impossible to eat
      1
      The dose

      A functional amount of a specific active — orders of magnitude past what any plate delivers.

      2
      The timing

      Delivered at the exact hour your biology can use it — not spread randomly across the day.

      So even on a perfect diet, WYN adds something food never can. That isn't nutrition — it's modulation.

      The point of all this

      So — should you elevate?

      "Sufficient" means your body isn't breaking. "Elevated" means it's running at its actual ceiling — sharper, more present, better recovered. Most people sit between the two and call it normal. Tap below to see where you actually sit.

      01Which best describes your day-to-day?

      02And honestly — how is each of these actually running?

      Your mornings
      Your afternoons
      Your evenings / sleep
      Where you want to land

      03Your read

      DeficientBelow the line SufficientGetting through ElevatedAt your ceiling
      Your read

      Tap your context, then the four states above

      We'll show where you actually sit on the spectrum — and which WYN formula moves the needle most for you.

      If your life only asks you to be "not deficient," eat well and you're done. If it asks for more — that's what elevated is for.

      — The diurnal cycle

      The world's first Diurnal State Modulation system, mapped end to end.

      One body. Eight biological states. Twenty-four hours. The orbit below is the spine of every WYN formulation decision.

      — World's first
      Tool 1 · The Diurnal Engine

      One body. Eight states. Twenty-four hours.

      See how your biological state shifts across the day — and why one supplement can't serve every state.

      How to use 1 Drag the dot across the 24-hour bar· 2 Switch the biomarker with the tabs· 3 Or press Auto Run to watch it play
      06:00
      Activation
      cortisol rising · sympathetic dominance
      What is happening

      Cortisol Awakening Response

      Cortisol typically rises around 50% in the 30–45 minutes after waking, mobilising glucose, raising blood pressure, and priming attention. This is healthy. Suppressing it is not.

      The opportunity

      Stack with the rise

      Layer tyrosine, ALCAR and adaptogens into the cortisol peak. Clean acceleration. No crash, because no synthetic energy was added — only what your biology was already trying to do.

      WYN protocol

      Morning · 06:00–09:00

      Morning mix dropped into water 15 minutes after wake. 18g of phase-matched actives. Designed to ride the wave, not replace it.

      Reading the curve

      Each line is one biological signal plotted across a full 24 hours; the dotted marker is the hour you're viewing. You're looking at cortisol — it rockets up after wake, peaks mid-morning, then drains to almost nothing by night. That shape is the whole point: a morning body and a night body need opposite chemistry, so one daily scoop can never fit both.

      Click a tab — swap to melatonin, dopamine, temp, ATP, HRV Drag the dot along the bar to move through the day Auto Run is playing — tap it to pause and scrub yourself
      Biological Layer nmol/L
      06:00

      How one system triggers the next

      Biology is a chain reaction — move one link and everything after it shifts. Click any node to see what it sets off, and where WYN steps in.

      Trigger
      Light
      Hits retina → SCN clock reset
      →
      Hormone
      Cortisol
      CAR fires within 30 min of wake
      →
      Neurotransmitter
      Dopamine
      Motivation, focus, drive
      Core
      Body temp
      Peaks ~18:00, drops at night
      →
      Hormone
      Melatonin
      Rises with darkness onset
      →
      State
      Sleep arch
      NREM → REM cycling, repair
      Tool 2 · The Body Simulator

      Tap a disruptor. Watch the whole system respond.

      Switch on a real-world disruptor and eleven downstream markers re-equilibrate live — because cortisol shifts HRV, HRV shifts dopamine, dopamine shifts sleep depth, sleep depth shifts inflammation.

      1Tap a scenario
      Cortisol & Melatonin · 24h
      Healthy Disrupted Melatonin
      Cortisol AUC?Total stress-hormone output across 24 hours. The 'always-on' load your adrenal system carries. You want it sharp in the morning, low at night.
      100%
      HPA total output
      HRV (RMSSD)?Vagal tone = how active your 'rest & digest' nerve is, read from heart-rate variability. Higher means a calmer, more adaptable nervous system.
      62ms
      Vagal tone
      Dopamine tone?How responsive your reward and motivation system is. Low tone feels like flatness and low drive — things stop feeling worth the effort.
      100%
      Reward sensitivity
      Core temp swing?How much your body temperature rises by day and falls at night. A bigger, cleaner swing means a stronger body clock and deeper sleep.
      1.20°C
      Circadian amplitude
      Slow-wave sleep?The deepest sleep stage (N3) — when the body physically repairs tissue and clears waste. More minutes means better recovery.
      95min
      N3 total per night
      REM sleep?Dream sleep — files memories and processes emotion. Too little leaves you foggy, flat and quick to react.
      110min
      Emotional consolidation
      Reaction time?How fast you respond on a simple alertness test, in milliseconds (the classic readout of sleep debt). Lower means sharper.
      220ms
      PVT median
      Mito efficiency?How cleanly your cells convert oxygen and fuel into energy (ATP). Higher means more usable energy from the same food and breath.
      100%
      ATP / O₂ ratio
      Inflammation?A blood marker of low-grade, body-wide inflammation (hs-CRP). Chronically raised, it quietly ages tissue. Lower is better.
      0.8mg/L
      hs-CRP proxy
      Recovery score?A single index blending the markers above — how ready your body actually is to perform today. Higher is better.
      92/100
      Composite index
      Glymphatic clearance?The brain's overnight waste-clearance system, active mainly in deep sleep. It flushes metabolic junk. Higher means a cleaner brain.
      100%
      CSF turnover index
      System verdict
      Baseline · all systems within healthy bounds

      2Or build your own

      Layer one or many disruptors. Each is a real-world insult to the diurnal system — the body adjusts instantly.

      From the problem to the protocol

      So — how does WYN actually help?

      You've seen the day your body runs, and what knocks it off course. WYN is three formulas, each dosed and timed to one window of that day. Let's start where the day starts.

      First product of the day Morning Tap to jump
      WYN MorningSee the product →
      Morning Activate · 15 actives · the energy + drive window

      What's in Morning — and why.

      Built around the cortisol wake-up and the cell's energy engine. Tap any active to see the science and what it does for you.

      What Morning actually does when you wake up.

      Not a caffeine slam. Morning rides the cortisol wake-up your body already runs — so you come online cleanly, hold focus through the day, and skip the mid-morning crash.

      First 20–30 minutes
      A clean lift — not a jolt.
      Feel

      Energy comes up like a dimmer, not a switch. Tyrosine and theacrine ride your natural cortisol rise, so there's no racing heart and nothing to crash from.

      Mid-morning · deep work
      Switched on, not wired.
      Feel

      ALCAR, CoQ10 and creatine fuel sustained mental output — sharper focus and faster recall without the jitter or tunnel-vision of a strong coffee.

      The usual 11–2 dip
      No mid-morning crash.
      Feel

      The energy is mitochondrial, not a sugar-and-caffeine spike — so it doesn't peak and collapse. The afternoon slump you expect simply doesn't arrive.

      Over a few weeks
      It gets stronger.
      Feel

      Day one is real, but PQQ is shown in preclinical studies to support mitochondrial biogenesis — the idea being a baseline that builds over weeks, rather than fading like a stimulant.

      Energy you can feel — but it's a rise, not a hit. No buzz, no shake, no 11am cliff.

      L-Tyrosine1,500 mg

      Raw material for dopamine and adrenaline — your drive chemicals.

      The science

      Under stress the brain burns catecholamines faster than it rebuilds them. Tyrosine refills the precursor pool.

      For you

      Focus and drive that hold through the morning, not just a caffeine spike.

      The scienceClose▾
      Acetyl-L-Carnitine2,000 mg

      Carries fat into the cell's engine to be burned for energy.

      The science

      Shuttles long-chain fatty acids across the mitochondrial membrane for beta-oxidation. Crosses into the brain too.

      For you

      Clean, physical energy that doesn't spike and crash.

      The scienceClose▾
      CoQ10100 mg

      Moves electrons down the cell's energy chain.

      The science

      Without enough CoQ10, electrons leak and become damaging free radicals; ATP output falls. It declines with age.

      For you

      More usable energy, less oxidative wear.

      The scienceClose▾
      PQQ10 mg

      Supports the cell's drive to build new mitochondria.

      The science

      Activates PGC-1α signalling — biogenesis. More engines, more capacity, built over weeks.

      For you

      Energy that compounds the longer you take it.

      The scienceClose▾
      Creatine3,000 mg

      Instant ATP recharge for brain and muscle.

      The science

      Recharges the phosphocreatine system — one of the most evidenced compounds for cognition and output.

      For you

      Sharper thinking and stronger physical work.

      The scienceClose▾
      Theacrine50 mg

      A caffeine-like lift — without the tolerance.

      The science

      Modulates adenosine and dopamine; trials of standardised theacrine showed no habituation at the doses studied, unlike classic caffeine.

      For you

      Sustained stamina, no peak-and-crash.

      The scienceClose▾
      Why together

      Tyrosine supplies the drive, ALCAR + CoQ10 + PQQ build the energy to act on it, theacrine sustains it and R-ALA shields it from oxidative wear. Substrate, engine and guard — together they hold a clean curve no lone stimulant can fake.

      Plus R-alpha lipoic acid, rhodiola, lion's mane, taurine, electrolytes, D3 + K2, methylated B-complex and BioPerine — full label on the product page.

      WYN SocialSee the product →
      Social Perform · 11 actives · the composure window

      What's in Social — and why.

      Built for words that land and calm under pressure. Substrate plus dampers — not a stimulant stack.

      What Social actually does when you're being social.

      Confidence, fluency and ease aren't personality — they're brain chemistry under pressure. Social tops up what social situations drain, so the version of you that shows up is the relaxed one.

      Walking in · first impressions
      You feel steady, not braced.
      Why

      High-stakes moments burn through dopamine and noradrenaline in minutes. Tyrosine keeps the tank full, so you read as confident instead of on edge.

      Mid-conversation
      The words arrive on time.
      Why

      Alpha-GPC feeds acetylcholine, the word-retrieval chemical. Recall and verbal flow sharpen — you stop stalling mid-sentence.

      The over-thinking
      The inner critic goes quiet.
      Why

      KSM-66 lowers cortisol and theanine raises calming alpha brain-waves. Less threat-monitoring means you loosen up and self-edit less — the social ease people chase from a drink, without the drink.

      Late in the night
      You actually enjoy the room.
      Why

      Saffron lifts mood acutely while tyrosine holds drive — so warmth and presence last instead of fading into tired and flat.

      It's not about losing control — it's removing the friction. Lower the stress signal, top up the drive and the words, and the easy, confident version of you is simply there.

      L-Tyrosine2,000 mg

      Refills the confidence chemicals before they drain.

      The science

      High-stakes moments drain dopamine and noradrenaline within minutes. A high dose buffers the drop.

      For you

      Composure where you'd usually freeze or go blank.

      The scienceClose▾
      Alpha-GPC300 mg

      Feeds acetylcholine — the word-retrieval chemical.

      The science

      The most bioavailable choline donor that crosses into the brain intact; lifts CNS choline in 30–60 min.

      For you

      Words arrive on time. Conversation flows instead of stalling.

      The scienceClose▾
      KSM-66 Ashwagandha300 mg

      Turns the stress dial down — without sedation.

      The science

      Standardised ashwagandha has been associated with reduced cortisol in controlled trials, by helping damp the HPA stress axis rather than sedating you.

      For you

      Calm under pressure — present, not flat.

      The scienceClose▾
      L-Theanine200 mg

      Switches the brain into relaxed-alert.

      The science

      Generates alpha-wave EEG activity within 30 minutes — the signature of calm focus.

      For you

      Easy and present, not wired.

      The scienceClose▾
      Saffron Extract30 mg

      Lifts mood quickly.

      The science

      Standardised saffron extract has shown mood-supporting effects in controlled trials, linked to its action on dopamine and serotonin.

      For you

      You actually enjoy the room you're in.

      The scienceClose▾
      Taurine1,000 mg

      Smooths the energy curve.

      The science

      Buffers catecholamine overshoot so the lift doesn't tip into jitter.

      For you

      Energy without the shake.

      The scienceClose▾
      Why together

      Tyrosine and Alpha-GPC supply the drive and the words; KSM-66, theanine and taurine keep the lift calm and the voice steady. Accelerator and brake in balance — that reads as composure, not a buzz.

      Plus rhodiola, theobromine, Dynamine®, a calibrated 80 mg caffeine and electrolytes — full label on the product page.

      WYN NightSee the product →
      Night Recover · 12 actives · the repair window

      What's in Night — and why.

      Built to protect deep sleep — the window where the brain rinses itself and the body rebuilds. Not a sedative.

      What Night actually does when you wind down.

      It won't knock you out — it's not a sedative. Night lowers the stress signal keeping you awake, drops you off faster, and protects the deep sleep that actually repairs you. The real payoff shows up the next morning.

      30–45 minutes after
      The edge comes off.
      Feel

      Calm, not drugged. Glycine, magnesium and KSM-66 lower cortisol and start the wind-down — your head quiets without that heavy, sedated feeling.

      Falling asleep
      You drop off faster.
      Feel

      Glycine nudges your core temperature down — the physical trigger for sleep onset. Less lying there with a busy mind, quicker to actually under.

      Through the night
      Deeper, less broken sleep.
      Feel

      It protects slow-wave and REM architecture so you complete full repair cycles — fewer 3am wake-ups, less tossing, more of the sleep that counts.

      The next morning
      You wake up actually recovered.
      Feel

      Deep sleep is when the brain's glymphatic clearance and growth-hormone repair happen — protect the sleep and you wake clearer and steadier, not groggy from a sedative.

      It doesn't sedate you — it removes what's keeping you up, then guards the sleep you get.

      Glycine3,000 mg

      Drops your core temperature to trigger sleep.

      The science

      Vasodilation lowers core temp ~0.3–0.5°C — the physical switch that starts sleep onset.

      For you

      Fall asleep faster, with deeper early-night sleep.

      The scienceClose▾
      Magnesium Bisglycinate300 mg

      Quiets the nervous system.

      The science

      Magnesium supports normal nervous-system and muscle function; the bisglycinate form is chosen for absorption and gut tolerance.

      For you

      The body lets go and muscles unclench.

      The scienceClose▾
      Apigenin50 mg

      Holds you in deep sleep.

      The science

      A chamomile flavonoid traditionally used to support calm and sleep continuity, without next-day grogginess.

      For you

      Fewer wake-ups, cleaner mornings.

      The scienceClose▾
      Phosphatidylserine400 mg

      Helps soften the overnight cortisol response.

      The science

      Phosphatidylserine has been shown to blunt the cortisol response to stress; the aim is a steadier second half of the night.

      For you

      Less likely to jolt awake in the small hours.

      The scienceClose▾
      Collagen Peptides5,000 mg

      Repair material for skin, joints and gut.

      The science

      Pro-Hyp-Gly peptides survive digestion and arrive during slow-wave sleep, when growth hormone peaks.

      For you

      Wake up rebuilt, not just rested.

      The scienceClose▾
      DHM (Dihydromyricetin)300 mg

      A calming flavonoid in the wind-down blend.

      The science

      A flavonoid from oriental raisin tree, traditionally used to support calm; studied for its interaction with GABA pathways.

      For you

      Part of the wind-down blend, not a sedative.

      The scienceClose▾

      Plus inositol, taurine, L-theanine, KSM-66, zinc and selenium — full label on the product page.

      09 — The whole system

      Three windows. One continuous rhythm.

      Each formula does one job at one time. The real design is the handoff: Morning sets the energy and catecholamine baseline, Social spends it when it matters, and Night rebuilds the substrate so Morning has something to work with tomorrow. Break one window and the next one starts in deficit.

      Morning
      06:00–10:00
      Social
      when it counts
      Night
      22:00 → overnight
      WakeOne 24-hour loopSleep
      Morning sets up the day
      BuildsCatecholamine substrate + mitochondrial ATP output
      Hands offA topped-up dopamine pool for Social to spend
      NeedsLast night's repair to have actually happened
      Social spends it well
      UsesThe morning substrate for words that land + calm
      ProtectsCortisol stays damped, so the day doesn't end frayed
      Hands offA nervous system that isn't over-revved at bedtime
      Night rebuilds the stock
      RestoresDeep sleep, glymphatic clearance, GH-driven repair
      ReplacesThe substrate Morning will draw on tomorrow
      ClosesThe loop — so day two doesn't start in deficit

      One scoop, any time of day, can only ever serve one of these windows. A day has three. So the system has three.

      — Your chronotype

      Lark, owl, or somewhere between?

      Five questions. Your chronotype is where your internal clock sits in the population — and it decides exactly when to take each WYN formula. Indicative profile, not a clinical MEQ.

      01 · Left entirely to your own schedule, when would you naturally wake?
      02 · When do you feel mentally sharpest?
      03 · For genuinely hard mental work, which window would you pick?
      04 · Without an alarm, getting up in the morning is…
      05 · When do you naturally feel ready for sleep?
      —
      —
      LarkIntermediateOwl
      —
      Self-report screen, not a diagnostic. For persistent sleep problems, see a clinician.
      Tool 3 · Your Alignment Score

      Your circadian alignment.

      Five questions. Sixty seconds. An indicative rhythm profile — not a medical assessment. Shows how aligned your day currently is, and which lever moves the needle most.

      01 · How many hours did you sleep last night?
      02 · When did you last drink caffeine?
      03 · Screen exposure in the last 60 minutes pre-sleep?
      04 · Bedtime variance across the last week?
      05 · Subjective stress load right now?
      0
      Alignment
       
       
      — How we rank the science

      What's proven, what's promising, what's still theory.

      Every active in WYN sits at one of four evidence tiers. We tell you which is which, throughout the page. Most-trusted at the top.

      Tier 01 · strongest
      Human Evidence
      RCTs · meta-analyses

      Multiple randomised controlled trials in humans at the dose we use, with peer-reviewed outcomes. Replicated across labs.

      Examples in WYN: Glycine 3g for sleep onset. Ashwagandha KSM-66 300mg for stress markers. Cortisol awakening response (Sleep Med Rev meta-review).
      Tier 02 · strong
      Established Mechanism
      Human + biochem

      Clear biological mechanism understood from in-vivo studies, with supportive (if smaller) human trials at the dose we use.

      Examples: Magnesium bisglycinate for GABA-A activity. Tyrosine for catecholamine substrate. CoQ10 for mitochondrial output.
      Tier 03 · moderate
      Biological Model
      Mechanism · early human

      Mechanism is mapped in lab models, with early-stage human signals. Promising direction; not yet at meta-analysis weight.

      Examples: PQQ for mitochondrial biogenesis. Phosphatidylserine for cognitive performance under stress.
      Tier 04 · emerging
      Forward Hypothesis
      Theoretical · preclinical

      Currently preclinical or theoretical. Included where the dose-response signal in animal models is strong and human risk is well-characterised. Treated as hypothesis, not promise.

      Examples: Some longevity-adjacent compounds. Anything we'd upgrade as the trials publish.
      The honest split. The 2017 Nobel Prize in Physiology recognised the molecular machinery of the circadian clock — that part of WYN's premise is extremely well-established science. What's still maturing is the per-compound, dose-and-timing literature for every active. We flag which is which at every step, and the references below carry their tier badge. Where the evidence is weaker, we say so.
      08 — Cited science

      The papers behind the formula.

      A working bibliography. We err toward primary literature, meta-analyses where available, and standardised-extract clinical trials. Where evidence is preliminary, we say so.

      01 · Cortisol
      Sleep Med Rev2010
      The cortisol awakening response: methodological issues and significance
      Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L.  ·  Sleep Medicine Reviews · 14(5):301–308
      Meta-reviewHuman
      Evidence Strong
      10.1016/j.smrv.2009.10.001
      02 · KSM-66 Ashwagandha
      Indian J Psychol Med2012
      A prospective, randomized, double-blind trial of a high-concentration full-spectrum ashwagandha extract in stress and anxiety
      Chandrasekhar K, Kapoor J, Anishetty S.  ·  34(3):255–262 · n=64 · RCT, double-blind, placebo-controlled · cortisol reduction 27.9%
      RCTHuman · n=64
      Evidence Strong
      10.4103/0253-7176.106022
      03 · Acetyl-L-Carnitine
      Aging Cell2005
      Acetyl-L-carnitine and α-lipoic acid: aging and mitochondrial function
      Pesce V, Fracasso F, Cassano P, Lezza AM, Cantatore P, Gadaleta MN.  ·  ALCAR + R-ALA restore mitochondrial DNA and respiratory complex function in aged tissue
      MechanisticAnimal
      Evidence Strong
      10.1111/j.1474-9726.2005.00150.x
      04 · Pyrroloquinoline Quinone
      J Nutr2006
      Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice
      Stites T, Storms D, Bauerly K, et al.  ·  PQQ stimulates mitochondrial biogenesis via PGC-1α and NRF1 signalling
      MechanisticAnimal
      Evidence Moderate
      10.1093/jn/136.2.390
      05 · Coenzyme Q10
      Front Physiol2018
      Coenzyme Q10 supplementation in aging and disease
      Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P.  ·  9:44 · Review of CoQ10 in mitochondrial electron transport and ATP synthesis
      Meta-reviewHuman
      Evidence Strong
      10.3389/fphys.2018.00044
      06 · R-Alpha Lipoic Acid
      Biochim Biophys Acta2009
      Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
      Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.  ·  1790(10):1149–1160 · Recycles glutathione, vitamin C, vitamin E
      MechanisticHuman + animal
      Evidence Strong
      10.1016/j.bbagen.2009.07.026
      07 · Theacrine
      J Int Soc Sports Nutr2016
      Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use
      Taylor L, Mumford P, Roberts M, et al.  ·  13:2 · No tolerance development over 8 weeks of daily 300mg use
      RCTHuman · 8w
      Evidence Moderate
      10.1186/s12970-016-0113-3
      08 · L-Tyrosine
      J Psychiatr Res2015
      Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands
      Jongkees BJ, Hommel B, Kühn S, Colzato LS.  ·  70:50–57 · Meta-review · Catecholamine precursor buffering under HPA load
      Meta-reviewHuman
      Evidence Strong
      10.1016/j.jpsychires.2015.08.014
      09 · Alpha-GPC
      Nutrients2015
      A randomized trial of alpha-glycerylphosphorylcholine on cognition and growth hormone
      Parker AG, Byars A, Purpura M, Jäger R.  ·  Acute cognitive performance improvement, BBB-crossing choline donor
      RCTHuman
      Evidence Moderate
      10.1186/s12970-015-0103-x
      10 · L-Theanine
      J Nutr2008
      L-Theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity
      Kelly SP, Gomez-Ramirez M, Montesi JL, Foxe JJ.  ·  138(8):1572S–1577S · Alpha-wave EEG signature of relaxed attention
      RCT · EEGHuman
      Evidence Strong
      10.1093/jn/138.8.1572S
      11 · Saffron Extract
      J Psychopharmacol2018
      Affron®, a standardised saffron (Crocus sativus L.) extract: randomised trials of mood and stress in adults
      Lopresti AL, Drummond PD, Inarejos-García AM, Prodanov M.  ·  Crocin/safranal acting on dopaminergic + serotonergic pathways; mood-supporting effects in controlled trials
      RCTHuman
      Evidence Moderate
      10.1177/0269881118822815
      12 · Glycine
      Sleep Biol Rhythms2007
      Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes
      Yamadera W, Inagawa K, Chiba S, Bannai M, Takahashi M, Nakayama K.  ·  5(2):126–131 · 3g glycine before bed shortened latency to sleep onset and to slow-wave sleep, and improved sleep quality
      Human trialHuman
      Evidence Moderate
      10.1111/j.1479-8425.2007.00262.x
      13 · Magnesium Bisglycinate
      J Res Med Sci2012
      The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled trial
      Abbasi B, Kimiagar M, Sadeghniiat K, et al.  ·  17(12):1161 · NMDA-receptor antagonism, GABA-A modulation
      RCTHuman · n=46
      Evidence Strong
      PMC3703169
      14 · Apigenin
      Pharmacol Biochem Behav1997
      Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor
      Salgueiro JB, Ardenghi P, Dias M, Ferreira MB, Izquierdo I, Medina JH.  ·  Apigenin binds BZD-site on GABA-A without next-day sedation
      MechanisticAnimal
      Evidence Moderate
      10.1016/S0091-3057(96)00424-4
      15 · Phosphatidylserine
      Stress2004
      Effects of soy lecithin phosphatidic acid and phosphatidylserine complex on the endocrine and psychological responses to mental stress
      Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D.  ·  7(2):119–126 · Blunts ACTH and cortisol response to acute stressors
      RCTHuman · TSST
      Evidence Moderate
      10.1080/10253890410001728379
      16 · Glymphatic Clearance
      Science2013
      Sleep drives metabolite clearance from the adult brain
      Xie L, Kang H, Xu Q, et al.  ·  342(6156):373–377 · Interstitial space expands ~60% during NREM, accelerates CSF-ISF exchange
      Landmark mechanisticMouse · in vivo
      Evidence Landmark
      10.1126/science.1241224
      17 · Chronobiology · Nobel
      Karolinska2017
      Nobel Prize in Physiology or Medicine — discoveries of molecular mechanisms controlling the circadian rhythm
      Hall JC, Rosbash M, Young MW.  ·  PER, TIM and CLOCK gene oscillation as the cellular timekeeping mechanism
      LandmarkMulti-organism
      Evidence Landmark
      nobelprize.org/2017
      18 · Hydrolysed Collagen
      Br J Nutr2015
      Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength
      Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D.  ·  Pro-Hyp-Gly bioactive peptides support connective tissue repair
      RCTHuman · resistance
      Evidence Moderate
      10.1017/S0007114515002810
      The contrast · one day, two outcomes

      The same day.
      Two different bodies.

      The same modern professional, measured two ways. Tap any ? to learn what each marker means. Longer gold bar = the body working with its clock, not against it.

      Status quo · modern life

      The unaligned day

      Late bedtime. Coffee at 14:00. Screens until lights out. Three years of chronic mid-grade stress.

      Diurnal State Modulation

      The aligned day

      Morning activation in phase. Social pre-load. Night architecture supported. Six weeks of consistency.

      Cortisol AUC?Your total daily stress-hormone load. You want it sharp in the morning and low at night. A flat, elevated curve keeps the body wired and wrecks sleep.lower load · better
      +34%
      Baseline
      HRV (RMSSD)?Heart-rate variability — the gap between heartbeats. Higher means a nervous system that recovers fast and isn't stuck in fight-or-flight.higher · better
      31ms
      71ms
      Slow-wave sleep?Deep sleep — when the body physically repairs tissue, builds bone and muscle, and clears metabolic waste. More minutes is better.higher · better
      52min
      98min
      REM sleep?Dream sleep — consolidates memory, processes emotion and steadies mood. Too little leaves you foggy and short-fused. More is better.higher · better
      68min
      114min
      Reaction time?How fast your brain responds, in milliseconds. A proxy for alertness and focus. Lower numbers = sharper, quicker thinking.lower · better
      312ms
      218ms
      Mito efficiency?How well your cells turn food and oxygen into usable energy (ATP). Higher means more real energy and less afternoon fatigue.higher · better
      −14%
      +6%
      hs-CRP?A blood marker of low-grade, body-wide inflammation. Lower means less hidden stress quietly ageing your tissues.lower · better
      3.4mg/L
      0.8mg/L
      Recovery score?A composite of everything above — how ready your body actually is to perform today. Higher means a body that bounces back.higher · better
      48/100
      94/100

      Illustrative biological model
      Illustrative contrast informed by published chronobiology — what the literature suggests can happen when intake is matched to the body's window vs when it isn't. The same compound, taken at the wrong time, behaves differently.

      Act 04 · The shift

      You don't need more energy.
      You need a body that's actually aligned.

      Three formulas. One system.
      Designed around the body you're actually in.

      Founders edition. £149/month for life. £50 to reserve. Closes at 250.

      Reserve a founders spot See the full system
      Reference

      Title

      Body

      Source